Endocrine Abstracts

A 63-year-old phenotypic male presented with absent testis and enlarged adrenal glands. He had attended the urology clinic for persistent microscopic haematuria. He was found to have an empty scrotum and hypospadias. The patient recalled having genital surgery in childhood but could not recall any endocrine assessment. He was taller than his peers in early childhood but stopped growing after age 13 years. He described himself as ‘potent’. He was unmarried and did not...

Introduction: Aminoglycoside exposure may result in hypomagnesemia, hypocalcaemia and hypokalemia. We describe a case of severe hypomagnesemia due to gentamicin therapy.Case report: A 46-year-old lady presented with ‘pins and needles’ and muscle cramps two weeks after being treated with gentamicin for biliary sepsis. Trosseau and chovstek signs were positive. Investigations showed hypokalemia, hypocalcaemia and hypomagnesemia (0.25 mmol/l (0.74...

Aim: To asses the significance of single 60 min serum cortisol level compared to conventional approach in short synacthen test (SST).Methods: Retrospective analysis of cortisol values in SST. Serum cortisol values at baseline, 30 min and 60 min were recorded. Rise of serum cortisol level to >550 nmol/l and a rise of >200 nmol/l from baseline is considered to be a negative test for hypoadrenalism.Results: About 168 patients ...

Introduction: We report a case of adrenal insufficiency as the first clinical manifestation of antiphospholipid syndrome.Case report: A 56-year-old male with no previous history of thrombosis was admitted with 3 stone weight loss and feeling generally unwell. He was hypotensive, pigmented and had a slate grey pigmentation of the nose. Chest auscultation revealed reduced breath sounds. Investigations revealed low sodium and high potassium levels with meta...